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Actalipid (Simvastatin)
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Simvastatin

Actalipid and MBCD Inhibit Breast Cancer-Induced Osteoclast Activity by Targeting Osteoclastogenic Factors. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Actalipid Survival Study (4S) Actalipid is classified as a Biopharmaceutics Classification System (BCS) Class-II compound with a poor aqueous solubility and an acceptable permeability through biomembranes.

Other names for this medication:
Simvastatin, Zocor, Actalipid, Lipex, Lipinorm, Lodales, Simcard, Simgal, Simvastatina, Simvor, Sinvacor, Sivastin, Vasilip, Zeid, Zocord, Zosta, Zostin,

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Students tended to overestimate the performance of fellow students, but acting as a standardized patient had educational value, and can be used to extend simulated patient encounters within the curriculum. LPS added to the supernatant was internalized by m-IC(cl2) cells and colocalized with TLR4.

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Hereditary persistence of alpha-fetoprotein is a rare disorder which exists with no simultaneous disease. Covert warfare against the immune system: decoy capsids, stealth genomes, and suppressors.

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A few peripheral metrocytes and many laminated myelin figure-like structures, probably degenerating merozoites, were found. The high concentrations of TOC, TN and BSi indicate the high nutrient level and diatom productivity in Zhelin Bay. This short review provides information on the compounds isolated between 1988 and 1992, and highlights interesting substances discovered during screening. Sperm bound to zona pellucida in hemizona assay demonstrate acrosome reaction when stained with T-6 antibody.

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Recording of spontaneous activity with photoetched microelectrode surfaces from mouse spinal neurons in culture. The changes also provide encouragement for zoos in developing countries such as China because greater visitor interest provides a strong argument and an incentive for improving welfare standards.

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To compare the characteristics and prevalence of the metabolic syndrome (MetS) among Native Indians, Inuit, and non-Aboriginal Canadians. Circulating levels of antibodies to HPV 16 may reflect recent HPV 16 infection or the frequency of past HPV 16 infection. The importance of estrogen-regulation of the small M(r) heat shock protein component of the stress response may be of particular significance to osteoblast physiology. The involvement degree of left and right hemisphere was examined during the processing of the first (L1) and second (L2) language in two different groups of bilinguals with English as L2.

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Principal component analyses illustrate the complexity of the interactions among risk factors, exposures, and outcomes. In this article, we present a study of SNPs by direct-contact electrical measurements to a single DNA duplex. Evaluation of estimated daily intake (EDI) of cadmium and lead for rice (Oryza sativa L.) in calcareous soils. When G protein was coexpressed with mutant subunits that formed trimers at the wild-type rate and were transported from the ER at the wild-type rate, heterotrimers were readily detected. This article opens a debate about how to think about moving forward with the emerging twin movements of human resources for health (HRH) and universal health coverage (UHC).

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Outcomes investigated include measurements of risk of asthma exacerbation. Can Measurements of Rectal Gas Increase Understanding of Chronic Constipation?

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Fibroblasts may participate in mast cell increase and inflammation in H. An array of genes related to antimicrobial biosynthetic pathways have been identified with whole-genome analyses of these strains. Successful Obliteration of a Pseudoaneurysm from Post-CEA Repair Secondary to a Pruitt-Inahara Shunt Using a Stent Graft. ResearchTraining.org and the AALASLearningLibrary.org are web-based learning management systems that utilise database architecture in Microsoft SQL Server 2000 and Internet browsers (Microsoft Internet Explorer 6.0, Netscape Navigator 6.0 browsers).

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Apparently the rodent LA muscle is an active component in a highly coordinated neuromuscular system augmenting penile erection and, contrary to its name, is most unlikely to participate in alimentary function. Acute myocardial infarct: the prognostic significance of complex coronary lesions We hypothesized that maternal characteristics acting to lower arterial O2 content would contribute to smaller infant birth weight. Simplified method for creating a density-absorbed dose calibration curve for the low dose range from Gafchromic EBT3 film.

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Phosphate transport in mitochondria: past accomplishments, present problems, and future challenges. Nevertheless, the Cs-engrailed-2 stripes eventually define the same border as the Cs-engrailed-1 stripes. All patients presented with severe abdominal or chest pain, which often was not radicular in character. Mechanically induced osteogenic lineage commitment of stem cells.

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We report for the first time electroretinographic (ERG) evidence of progressive retinal abnormalities in a girl who presented in infancy with ocular features of albinism and gradually developed choroidal sclerosis and patchy retinal atrophy leading to a diagnosis of Knobloch syndrome (KS, OMIM 267750, COL18A1). The mandible is the most frequently involved site, in particular the third molar region, mandibular angle, and ramus.

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These cells contain nuclear T3 receptors (RT3) which are products of c-erb A alpha proto oncogenes, and are down-regulated by T3. Analyses of variant acid beta-glucosidases: effects of Gaucher disease mutations. Depression has been postulated to be a mediating factor between low serum cholesterol and suicidal behavior.

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A model which considered the effect of axial dispersion was successfully used to describe the fixed-bed operation behaviour for the lower flow rates. The spectra of cellular reactivity and size of respective antigens indicate that these MAbs appear to react with determinants of chicken B lymphocytes that had not been previously described. Clinicians believed CRP POCT could support decision-making for some presentations of ARTIs and patient populations when used in conjunction with clinical criteria. In a broader sample of 22 patients with psychosis, the allele frequency of the rs10666583 mutation variant was increased compared to those of healthy population samples and unaffected relatives. Computed tomography 1 week postoperatively demonstrated closure of the primary entry tear with thrombosis of the false lumen in all cases.

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Coronary artery disease and its risk factors in patients presenting for liver transplantation. Self-reported vision health status among older people in the Kassena-Nankana District, Ghana. The results indicate that different methods of processing barley had no detectable effect on dry matter intake, average daily gain, and feed efficiency and that skeletal growth, health, and rumen pH were not affected by dietary treatments.

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This study was implemented to address the inability of a subset of the Zorbax SB-CN columns used in this method to adequately perform this separation, which were otherwise indistinguishable from columns of this type that could. However, it has been found that axial strips sectioned from arteries also curled into arcs, showing that the axial residual stresses were relieved from the arterial walls. Challenged females refrained from breeding only in the unfavourable year, but no downstream effects were found in either year.

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Ovarian tissue was vitrified with the use of two vitrification methods. Cancer pain patients reported a reliably higher affective loading to their pain. In order to examine the direct actions of the NO donor sodium nitroprusside (SNP), this study used in vitro specimens of the rat pancreas where the distribution of neuronal nitric oxide synthase (NOS) and the secretory effects of SNP and the cyclic GMP (cGMP) analog 8-bromo cyclic GMP (8-Br cGMP) were investigated. Among them, 35 PCOS patients accompanied with NAFLD were recruited as Group A, and 35 PCOS patients without complicated NAFLD were recruited as Group B.

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Influence of sampling window size and orientation on parafoveal cone packing density. Vinyl carbamate reacted with dimethyldioxirane in dry acetone to give a high yield of pure crystalline vinyl carbamate epoxide. The ensuing functionalized NiNW exhibited the characteristic green fluorescence of FITC and could be magnetically separated from aqueous solutions by using a NdFeB magnet. Routine reevaluation in addition to patient education is the best assurance for a favorable, sustained outcome. 2 cases of severe NMG complicated by chronic lung disease and pulmonary arterial hypertension are reported.

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Cytochemical criteria of the effect of the climatotherapy of chronic glomerulonephritis The pathophysiology of post-resection liver failure is difficult to reverse and thus strategies aimed at prevention are key to reducing morbidity and mortality after liver surgery. Numerous synthetic and natural substances have endocrine-disruptive effects, acting through several mechanisms.

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Correlative factors of left ventricular hypertrophy in end-stage renal disease. These results may have important implications for the mechanism of HIV pathogenesis.

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Although reduced-frequency AVB was associated with improved carryover of a therapeutic vocal behavior (i.e., reduced vocal intensity) in a patient post-excision of vocal fold nodules, causation cannot be assumed. In addition, colocalization of IRS-1 and 14-3-3 was observed in the cytoplasm after insulin treatment by confocal microscopy. Recently, the discovery that heavy chains could be involved in amyloid formation led to the designation of this type of disease process as AH amyloidosis.

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The imaging data were analysed using the seed-based functional connectivity method. Clinicians should be aware of the association of this rare primary neoplasm of the breast.

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Short-term release cues to stop-consonant place of articulation in child speech. Possibilities and perspectives of screening as a weapon against ischemic heart disease Forty-nine children were enrolled in this study with suspicion of pyelonephritis. The power of the graphic display is presented by the following application of the program.

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Esophageal granular cell tumor associated to squamous cell carcinoma: a case report However, histological examination did not show typical syphilitic features.

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In patients with limited EMS and in control patients without heart failure but extended EMS, oxygen uptake can be improved but EF is unaltered. The relationship of plasma urea nitrogen with growth traits and age at first estrus in gilts. one hundred and ninety-five Dunedin and 94 Uppsala residents were chosen randomly from the respective populations, in the former city by electoral roll, in the latter by use of unique personal number. Novelty and significance effects in the fractionation of phasic OR measures: a synthesis with traditional OR theory. Seventy percent of dentists, however, had patients who took antibiotics before a dental procedure even though the guidelines no longer recommend it.

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The levels of C4bp-S decreased as the levels of aCL, particularly IgG, increased. UVA1 phototherapy is an important asset in the reduction of clinical manifestations in morphea. A 58-year-old man had an asymptomatic tight stenosis of the internal carotid artery associated with a persistent proatlantal artery.

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Surface reduction of amorphous NiS particles potentiates their phagocytosis and subsequent induction of morphological transformation in Syrian hamster embryo cells. The zebrafish provides an ideal system in which to perform genetic and chemical screens to identify new pathways involved in tendon biology.

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Quantity of circulating IgG reactive to these peptides was also discussed. First, the group identified the optimal properties of a symptom screening tool for pediatric cancer patients. To this end, we injected corticosterone (5 mg/kg) on 7 scattered days during the peripuberty period (P28-P30, P34, P36, P40, and P42), following the same experimental schedule as for stress administration in our peripubertal paradigm. Lack of inhibition by colicin M suggests bactoprenol independence of MDO biosynthesis.

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31st annual meeting of the British Association of Cancer Research and the 5th annual meeting of the Association of Cancer Physicians. In contrast, color flow ultrasound provided little additional information in 7 patients with intrascrotal masses. Use of Magnesium compositum in arteriosclerosis of the vessels of the heart, brain and lower extremities By postnatal day 24, neurons which provide serotoninergic projections to the lumbosacral cord were especially numerous and some of them were found in areas which do not provide comparable projections in adult animals. Practical implications The findings elucidate a potential underlying cause of problems in hospital management in Indonesia and may inform culturally appropriate ways of addressing them.

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The involvement of Kupffer cells in the clearance of high molecular weight rat IgA aggregates in rats. These findings explain the opposite effects of ERK1/2 stimulation on apoptosis found in different cell types and suggest that local activation of ERK1/2 signaling may account for the opposing response to oxidative stress by Ha-Ras or Ki-Ras-expressing cells. Cholinergic crisis following administration of distigmine bromide: a case report Albuminuria and associated medical risk factors: a cross-sectional study in 451 type II (noninsulin-dependent) diabetic patients.

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Thirty-one patients underwent initial and follow-up pure tone audiometry examinations. Immediate evaluation of the interface by scanning electron microscopy and histologic examination confirm the blood compatibility of the material, that is, limited platelet and erythrocytic activation or fibrin formation, or both.

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Specifically, we have implemented a live jump detection and force-clamp algorithm that intelligently adjusts and maintains the force on a single molecule in response to the measured state of that molecule. Post LASIK progressive astigmatism in a child with partially accommodative esotropia. Using a post-transfer editing deficient mutant of IleRS (IleRSAla10), we were able to achieve ribosomal incorporation of TfeGly in vivo. The prevalence of stenosis of the internal carotid in subjects over 49: a population study

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In this study, the PGF(2 alpha) and PGE(2) content of, and production in vitro by, day 10-32 equine conceptuses were measured and the influence of pregnancy on the concentrations of these prostaglandins in the uterine lumen was examined. Antibody-independent inhibition of Plasmodium falciparum in vitro cultures. coli and that the cspA homologues in these two psychrotrophs were expressed constitutively at a low level both at 4 degrees C and 22 degrees C. As a consequence, these reciprocal associations could result in a vicious cycle of deterioration that likely contributes to increased mortality. This method may provide a general approach for studying the dynamics of protein phosphorylation-based signal transduction in living cells.

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This study indicates that the natural proteinase-activated receptor agonists thrombin and MC tryptase might sustain liver fibrosis by promoting stellate cell proliferation and collagen synthesis. Colocalization of the calcium-binding protein calretinin and NADPH-diaphorase activity at the cellular level was studied in the magnocellular secretory nuclei of the rat hypothalamus using sequential immunocytochemical and histochemical staining of the same sections. In addition, the combination of a suboptimal dosage of interferon gamma with ASA resulted in a significantly higher survival rate compared to the untreated controls. The incidence and cost of hospitalization for 5-FU toxicity among Medicare beneficiaries with metastatic colorectal cancer. Dose- and time-response relationships of triethylenemelamine-induced chromosomal aberrations in rat bone marrow cells.

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Pyuria and bacteriuria in urine specimens obtained by catheter from young children with fever. Ultrasonography can provide an early diagnosis and effective treatment can be achieved with percutaneous catheter drainage in combination with appropriate antibiotic therapy. Cellular membrane potentials and contractile threshold in mammalian skeletal muscle susceptible to malignant hyperthermia. Thus, directly identifying compounds that can modulate excitotoxicity-induced neurodegeneration and subsequently clarifiying the molecular mechanism is a valid approach to develop effective strategies to suppress neurodegeneration.

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The study provided evidence that 5-FU and MMC biological delivery membranes could significantly improve the outcome of filtering procedures, the survival of the bleb, and maintenance of lower IOP. Regulation of tubulin levels and microtubule assembly in Saccharomyces cerevisiae: consequences of altered tubulin gene copy number. MAC-ABC(DKO) bone marrow (BM) was transplanted into Ldlr(-/-) recipients. In the evaluation of long-term rodent carcinogenicity studies, many different tumor sites and types are evaluated, which may increase the likelihood of a statistical false positive. In both studies, blood samples were collected on the first and last study day for the analysis of plasma concentrations of sildenafil and its primary metabolite, UK-103,320.

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Studies in (Wistar/Furth x F344) F1 hybrid recipients grafted with mammary cells from either parent strain demonstrated that this difference in DU formation is dependent on the strain of grafted MtT, and is not a genetic characteristic of the rat strain. Although the majority of patients can be easily weaned from mechanical ventilation, a substantial minority pose considerable difficulty. Complex rehabilitation of patients operated on for complicated peptic ulcer We investigated whether Mycoplasma induced inflammatory cytokine secretion through TLR2-mediated mechanism in prostate cancer cell line.

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Analysis by polymerase chain reaction (PCR) has demonstrated that the ulcers are frequently caused by herpes simplex type 2 (HSV-2), although HSV-1 is becoming increasingly important in many parts of the world. Accumulation of autophagosomes in breast augmentin 500 125 mg comprimidos masticables cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5. The present study investigated the effect of intensive (INIT) versus conventional insulinotherapy (COIT) in cardiac surgery patients who received cardiopulmonary bypass (CPB). The wetting behavior of a series of aliphatic polyamides (PAs) has been examined. The present article gives a review about roentgenographic findings of the chest in idiopathic respiratory distress syndrome of the newborn and in bronchopulmonary dysplasia.

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Computer-based quality of life questionnaires may contribute to doctor-patient interactions in oncology. To investigate the levels of circulating ADMA perten glutomatic price and sVCAM-1 in patients with pheochromocytoma. Medical resource utilisation and cost of care for women seeking treatment for urinary incontinence in an outpatient setting. A further modification gives estimates of ratios as a function of a continuous covariate and time. If pregnancy does not ensue, in vitro fertilization and embryo transfer are the next line of management, and results are optimized by prior medical therapy and aspiration of endometriomas.

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Almost all the available information is related to changes in laboratory values and surrogate outcomes. This was quite consistent for the annulus fibrosus in all regions and there were dramatic decreases gabitril vs gabapentin uses in the lumbar nucleus pulposus in all adults compared with infants and children. Further elucidation of these mechanisms may suggest interventions directed towards inhibiting the pathophysiologic sequelae of endothelial cell activation. FL118 selectively inhibits the expression of four major cancer survival-associated gene products (survivin, Mcl-1, XIAP, and cIAP2) and shows promising antitumor activity in animal models of human cancers when administered using a weekly x 4 schedule (Ling et al., PLOS ONE.

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We argue that community outreach efforts should be characterized by three components: 1) careful mapping of high-risk areas, 2) developing partnerships with fenofibrate 200 mg obat apa vibrion trusted community institutions within areas of high risk, and 3) developing a portfolio of institutional partners that maximize the penetration of high-risk populations. The study investigates severity of alcohol dependence among drug misusers. The National Board of Health and Welfare together with Riks-Stroke (the Swedish National Registry for Quality Assessment of Acute Stroke Care) initiated a follow-up 2 years after a stroke event in 10,303 individuals, registrated in Riks-Stroke during the first 6 months of 2001. The effects of different patterns of mechanical ventilation on the respiratory mechanics and gas exchange in dogs severely injured by steam inhalation Thus, three new surface coatings of small synthetic grafts were tested in an acute pig model to evaluate their thrombogenicity (extracorporeal arterio-venous shunt) and in a chronic rat model to evaluate the tissue reaction they induced (subcutaneous implantation).

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In children over 5 years of age the features resembled those in adults, but in those under this age they were often nonspecific including fever, convulsions, diarrhoea, and vomiting. Standard differential equation-based models of collective cell behaviour, such as the logistic growth model, invoke a mean-field assumption which is equivalent to assuming that individuals within the lortaan medicine for diarrhea population interact with each other in proportion to the average population density. Grapefruit juice caused a small decrease in the plasma concentrations of acebutolol and diacetolol by interfering with gastrointestinal absorption.

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Our data indicate that ER stress and autophagy may play a role in the apoptosis that is induced by the curcumin analogue B19 in an epithelial ovarian cancer cell line and that autophagy inhibition can increase metrogel topical 1% gel coupon curcumin analogue-induced apoptosis by inducing severe ER stress. The hydrocele of the canal of Nuck is quite a rare condition and results from the failure of obliteration of the distal portion of evaginated parietal peritoneum within the inguinal canal which forms a sac containing fluid.

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Diagnosis and treatment of hereditary hemochromatosis: an update. O-GT and N-MAT appeared to be monomeric polypeptides with isoelectric points of approximately 4.8 and approximately 6.1, respectively. The suppressive activity of the cells was not affected by treatment with indomethacin or anti-Thy-1, anti-Ig, alprazolam 0 25mg reviews on fuller anti-Ia, or anti-asialoGM1 plus complement.

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Morphological changes are evident in rectal, muscle or nerve biopsies. Omani henna from Al-sharqyia region demonstrates high in vitro anti-P. It also discusses the trade-offs policy makers may face to resolve these challenges in the context of rising premiums and a slowing economy. In this article Nico van Rooijen postulates that, in the continuing presence of soluble antigen, the newly generated memory B cells in soviclor aciclovir 800 mg the follicles may continue to differentiate into antibody-forming cells. Similar results were obtained upon delivery of IL-2 into the mouse brain using osmotic minipumps or injection of mice with recombinant IL-2 protein, IL-2 DNA, or IL-2 synthetic peptides prior to infection with wild-type (wt) HSV-1 strains McKrae and KOS.

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Retrospective cohort study using logistic regression with split validation. Moreover, this paper emphasizes the necessity to evaluate the in vitro models of the endothelium with respect to the extrapolation to the situation in vivo. Western blot analysis augmentin pregnancy necklaces of the rat gastric mucosal extract with polyclonal antihuman FN antibody showed that this substance has a molecular weight of about 70,000 Da.

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Acute Cardiovascular and Hemodynamic Responses to Low Intensity Eccentric Resistance Exercise with Blood Flow Restriction. The scapular inferior distance after detailed assembly was significantly increased compared with that before detailed assembly work. Based on this case report and on the previously pantorc 40 mg effetti collaterali radio reported five cases of pedunculated AA arising from the vulvovaginal region, including one tumor arising from the vaginal suburethral area, it seems that pedunculated AAs arising from the vulvovaginal region are at negligible risk of recurrence after local excision. A case series of 11 such patients with flat corneal topography is presented and their management described. The intraobserver and interobserver kappa values concerning reproducibility of diagnoses were higher for histological specimens (0.80 and 0.74) than for cytological specimens (0.70 and 0.61).