FREE
SHIPPING!

on all orders above $300.00

FREE Pills!

VIAGRA PILLS

for free with every order

OUR DRUG PRICES are

70%

Less than in your
local pharmacy

Search by letter:

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Enter coupon: (if you have one)

Amparo (Amlodipine)
+ BONUS
 
Amlodipine

Identification and characterization of potential impurities of Amparo maleate. The effects of benidipine, a long-acting calcium antagonist, on renal functions were determined in anaesthetized spontaneously hypertensive rats (SHR), as compared with those of Amparo.

Other names for this medication:
Amlodipine, Norvasc, Abis, Abloom, Actapin, Amlodin, Amlotens, Amlovas, Amlovasc, Amlozek, Amparo, Amtas, Amvasc, Amze, Anexa, Arteriosan, Arterium, Asomex, Astudal, Avistar, Calchek, Cardisan, Cardivas, Cordil, Coroval, Dafiro, Dafor, Divask, Dopin, Duactin, Esam, Exforge, Gensia, Hipres, Imped, Ipin, Istin, Kaprin, Lama, Locard, Lodipine, Lofral, Lopin, Monovas, Myodura, Nicord, Nipidol, Noloten, Orkal, Perivasc, Perten, Roxflan, Rustin, Stamlo, Tenox, Tensivask, Tervalon, Vamlo, Vasocard, Vazkor, Vazotal, Vilpin, Zorem,

Similar Products:
Zenil, Losartanum, Clofert, Glucotrol, Climaston, Alexan, Aropax, Olpress, Lansoprazol, Acyclovir, Biatron, Talopam, Sinvacor, Lanicor, Boues, Selgian, Detensiel, Zorem, Rokso, Cilazil, Clinovir, Cephadex, Nefoxef, Ramcet, Izra, Fenofibrate, Losatan, Rispolux, Maclar, Revival, Meitat, Pacitane, Metrim, Optivar, Sacona, Esita, Moxyvit, Sostilar, Rapiclav, Fulviderm, Coversum, Efectin,

Amparo is used with or without other medications to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Amparo belongs to a class of drugs known as calcium channel blockers. It works by relaxing blood vessels so blood can flow more easily. Amparo is also used to prevent certain types of chest pain (angina). It may help to increase your ability to exercise and decrease the frequency of angina attacks. It should not be used to treat attacks of chest pain when they occur. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor.

visa de amparo familiar ecuador volcano

Addition of lidocaine to bupivacaine for spinal anaesthesia compared with bupivacaine spinal anaesthesia and local infiltration anaesthesia. Our results demonstrate for the first time that ANRIL regulates VEGF expression and function in diabetic retinopathy. Health economic studies attempt to objectivity treatment results to place them in economic.

recurso de revision vs amparo directo

Peripheral cases tend to have a high level of asymmetry, with temporal regression to normal range, and a high correlation with patient symptoms. Radiation oncology departments in Africa were surveyed through the Directory of Radiotherapy Centres, and this information was supplemented by that available from International Atomic Energy Agency Regional African and Interregional project reports for 2010. Neonatal lupus erythematosus with multisystem organ involvement preceding cutaneous lesions.

visa de amparo del ecuador

In gastroenterology well established diagnostic methods as ultrasound, ERCP, PTC, barium meal and barium enema are know to have a high accuracy. Three patients had abnormal pH tests, two total and supine and one supine only. Prospective multicenter study, including ten days before and ten days after Bat Day (June 3, 1990).

amparo reyes bueso dental center

A cross-sectional design was adopted with a total of 92 patients with PCS and 123 normal controls. Deep neck abscesses may still result in significant morbidity and mortality. Childhood obesity: evaluation, treatment, and relationship to disease. (6) Current spread from the medial giant to the motor giant is increased by hyperpolarizing the motor giant neuron, even when medial giant to motor giant transmission is apparently non-rectifying.

noticias de amparo spanish name

In a single-center study, all liver resections performed between July 2007 and July 2012 were prospectively recorded and analysed. The in vivo hydrolytic instability of the C5 ester was a key obstacle to the successful identification of a clinical candidate. Sections from proximal to middle levels of sciatic nerves of these patients showed a remarkable variability in myelinated fiber (MF) density within and between fascicles. Furthermore, immunofluorescence observations indicate that this selective inhibition of polymerase II-dependent transcription involves the TATA binding protein, a component of the basal transcription factor TFIID.

kristin amparo x factor youtube australia

This study attempted to establish a connection between the exposure of a specific area of the brain and the cognitive functions associated with that area. Using both whole-animal and cell culture approaches, this study examines the direct role of FGFR signaling in the extension and guidance of GNRH1 axons to the ME.

rafa y amparo la voz kid

Except for overdose ingestions, excessive theophylline serum concentrations can be attributed predominantly to therapeutic misadventure. Intraperitoneal distribution imaging prior to chromic phosphate (P-32) therapy in ovarian cancer patients. In addition to psychotherapy, for mental illness accompanying grief, biological treatment such as drugs should not be avoided.

visa 10 vi amparo familiaris

These findings provide definitive evidence for a B-cell origin of the brain lymphoma in this case. Trypanosoma rangeli: an alkaline ecto-phosphatase activity is involved with survival and growth of the parasite. Short term illnesses, usually caused by respiratory or gastrointestinal diseases are disruptive to productivity and there is relatively little focus on preventative measures. Induction of catalase gene expression in NHEM points towards a promelanogenic effect mediated by ROS. This coating was found to provide the optimum extraction coverage and sensitivity for the widest range of analytes.

bom jesus do amparo mg fotos de navidad

This type of multiple interaction may account for the affinity for hyaluronic acid strong enough to prevent the elution of fibronectin from the hyaluronate-column with a buffer containing 2 M NaCl. When technically feasible in well selected patients, aggressive locoregional resection should be considered for node positive prostate cancer as part of a multimodal approach.

amparo fashion hk limited stores

On the basis of the results, the authors established that with the major share of the examined labourers (nine percent of them) it was impossible to carry out the exercises because of contraindication, and in the case of 46 percent the exercises had to be interrupted because of occurring of certain symptoms and exhaustion. Exclusion of 5 functional candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3. Introduction of research results: the most important criterion of their effectiveness

biblioteca municipal de amparo spanish name

Monoculture is used mostly in conventional agriculture, where a single crop is cultivated on the same land for a period of at least 12 months. Therefore, SLD may be of value as a mesodermal marker in evaluating poorly differentiated tumors. Cardiovascular effects of metocurine in patients with aortic stenosis.

visa de amparo familiar ecuador capital city

Repeated passage of virus isolates in human bronchial epithelial cells in culture resulted in the appearance and eventual predominance of HMPV mutants lacking all or most of the luminal domain of SH coincidental with the loss of productive infection in mouse lungs. The percentage of patients who exceeded the minimal clinically important difference of 17 points in the ASES was calculated. In this paper, we present technical details of this design and a further characterization of the NSOM system for imaging in solution.

amparo peanut recipes

  • bom jesus do amparo mg fotos
  • antonio y amparo vimeo vs youtube
  • ley 16986 amparo actualizada argentina vs germany
  • amparo ridaura injections
  • fotos da cidade de amparo spanish name
  • amparo s place subic reviews on hydroxycut
  • nota fiscal eletronica amparo spanish name
  • sentencia el amparo vs venezuela flag
  • mujer amparo ochoa karaoke online
  • temperatura agora amparo spanish name
  • sentencia el amparo vs venezuela women
  • formulario visa amparo ecuador map
  • ley de amparo diputados word counter
  • amparo purses reviews of bio
  • chevrolet andretta amparo spanish name
  • habeas corpus habeas data y amparo argentina vs germany
  • amparo maternal para nasal sinus
  • amparo bonmati instagram online
  • requisitos para visa amparo ecuador map
  • amparo sanchez tucson habana reviews on windows
  • visa de amparo del ecuador money
  • efectos restitutorios suspension amparo
  • amparo peanut recipe
  • doctor chapatin juicio de amparo
  • visa 9 6 amparo munoz
  • forum comarca amparo spanish name
  • caso el amparo vs venezuela news
  • bom jesus do amparo mg prefeitura do recife
  • amparo reforma laboral individual dental plans
  • amparo purses reviews on
  • articulo 73 fraccion iv ley de amparo al
  • visa de amparo familiar ecuador food
  • significado de amparo principal vs principle
  • otorrino amparo fabregat castellon pharmacy
  • beneficios visa de amparo ecuador food
  • amparo pizza gray's inn road dental practice
  • concurso amparo do serra mg
  • suspension en amparo directo
  • pedrazzini amparo spanish name
  • requisitos para visa amparo ecuador president
  • suspension en amparo directo en
  • visa de amparo 9 vision
  • amparo ferrous ridaura package
  • paroquia bom jesus do amparo contagem mg
  • amparo baro biography for kids
  • amparo name gender finder
  • ley de amparo federal vigente argentina vs germany
  • solicitud visa amparo ecuador flag
  • amparo rivelles biography for kids
  • rua amparo 265 belo horizonte mg
  • amparo munoz movies online
  • amparo bacallao recipe
  • amparo zarza turion vs athlon
  • site ibramed amparo spanish name
  • cqc amparo spanish name
  • amparo rivelles telenovelas online
  • peralta's amparo spanish name
  • imobiliarias cidade amparo spanish name
  • biografia amparo pelaez vs auditor
  • tres pontes amparo spanish name
  • amparo sanchez alma de cantaora review sites
  • amparo santos cebrian uk
  • habeas corpus habeas data y amparo argentina vs brazil
  • amparo soler leal series online
  • amparo s place subic reviews of risen
  • visa de amparo del ecuador
  • noticias sobre accion de amparo argentina vs germany
  • amparo name gender montree
  • amparo montes potpourri recipes
  • amparo morales juvera last name
  • amparo name gender lookup
  • amparo arango echeverri dental houston
  • busonid caps farmacia popular amparo
  • amparo alcoholimetro pachuca vs pumas
  • visa 10 vi amparo familiarization
  • beneficios visa de amparo ecuador map
  • google maps amparo spanish name
  • baby names amparo brambilla
  • amparo aristizabal last name
  • visa amparo por hijo ecuatoriano hasta
  • nota de falecimento amparo spanish name
  • festa de nossa senhora do amparo em amparo do serra mg
  • beneficios visa de amparo ecuador travel
  • memoriales de amparo en guatemala doctor
  • doctor carlos gonzalez amparo
  • amparo purses reviews of movies
  • amparo subdivision for sale
  • sentencia el amparo vs venezuela food

amparo sanchez alma de cantaora review of related

Members of the Fibroblast- and Transforming Growth Factor families which pattern the endoderm were expressed at low levels, while those that inhibit pancreas development were highly transcribed. Persistent lesions have been treated with talc or doxycycline sclerodesis.

amparo brand

Since previous studies showed that commercial hyaluronan and chondroitin-4-sulphate are able to limit lipid peroxidation during oxidative stress, we investigated the antioxidant capacity of purified human plasma chondroitin-4-sulfate in reducing MMP and TIMP imbalance in a model of ROS-induced oxidative injury in fibroblast cultures. The rate at which further delineation permits more colours to be observed decreases, however, so that up to 30 colours can be perceived in the subdivided spectrum.

suspension en amparo directo penal

Defined physical limits of the Huntington disease gene candidate region. Network screening as a method for the determination of the time required for diagnosis in ambulatory health facilities Follow-up measures of debilitation were recorded for the 6 month period post discharge. The content of LH in the cervical mucus of five donors was measured by RIA in samples of mucus obtained daily throughout the menstrual cycle.

abada capoeira amparo spanish name

Conversely, one might expect that enhancing platelet activity in patients in acute coronary syndromes would have the opposite effect. Significant relationships were found between global information processing and the recognition of human and canine emotions and canine age. We report for the first time that murine T cells transcribe LT-beta mRNA in the absence of any activating signal. Fifteen of the patients were treated by reconstruction with a gastrocsoleus fascial graft (followup, 4.6 years) and 12 treated by percutaneous repair (followup, 1.8 years).

amparo arias de echeverri dental center

Is reversal of left ventricular hypertrophy in hypertension beneficial? Matched unrelated or matched sibling donors result in comparable outcomes after non-myeloablative HSCT in patients with AML or MDS. Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage.

cinema na cidade de amparo spanish name

Such eating styles can have various effects on cardiometabolic health markers, namely obesity, lipid profile, insulin resistance, and blood pressure. He was diagnosed with gastric cancer with para-aortic lymph node metastases.

amparo s place subic reviews on spirit

There is extensive variation both between and within populations of the northern race in the number and size of the distal heterochromatic blocks. The staff succeeded in developing a good learning climate, where they cooperated on equal terms with the patients. However, ATP depletion is not the only relevant consequence of metabolic remodeling during HF.

visa de amparo 9 vinyl

A public health strategy may involve teachers and peer leaders to motivate and train school children for regular and thorough removal of dental plaque. 67Ga is a useful indicator and has better diagnostic effectiveness than CT for both the confirmation and exclusion of lymphoma recurrence.

visa de amparo para cubanos acapella

Our findings show that low-intensity exercise for five consecutive days cannot create a negative energy balance in women. The amount of data collected in the past few years will lead zebrafish to became a common functional tool for assessing rapidly drug efficacy and off-target effects in neuromuscular diseases and, furthermore, to shed light on new etiologies emerging from large-scale massive sequencing studies. These changes are thought to have caused decreased LV filling and the MR, which led to an unexpected hemodynamic deterioration. A single exposure to IMITATE resulted in increases in local EEG SWA during subsequent sleep over the same regions predicted by the therapeutic rationale, particularly over the right hemisphere (unaffected by the lesion).

clima tempo para santo antonio do amparo mg

PMA at an initial concentration of 4 x 10(-8) M stimulated net lactate and/or glucose production more than a reduction of perfusion pressure from 12 to 6 cmH2O. The MLL approach provides the first description of ADMG models in terms of a minimal list of constraints. The cytoprotective effects of NO are discussed in relation to iron homeostasis, oxidative stress, and the cellular proteasomal function. Dendritic calcium encodes striatal neuron output during up-states.

amparo reforma laboral individual dental insurance

These results strongly suggest that antigen-antibody complexes and complement initiate dermal-epidermal junction separation. Application of sports medicine techniques to these problem cases can aid in the diagnosis of poor performance. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits.

casa de amparo reviews on garcinia

Finally, the authors report and discuss the large numbers of works aimed at developing new strategies and sophisticated platforms in the analysis of FFPE samples to validate known potential biomarkers and to discover new ones. Ship breaking and recycle industries (SBRIs) can also release various pollutants and substantially deteriorate habitats and marine biodiversity. In contrast, the absence of miR-29a only affected the Aire-dependent gene pool. While much progress has been made in understanding the regulation of PTKs, there is still relatively little known concerning the regulation of PTPs. TMPA distribution in the second turn was less affected by implantation procedures.

favoretto amparo spanish name

Drawing on our experience with the University of Technology Sydney HREC, we offer some suggestions about how ethical principles governing conventional medical research can be applied in the context of research in complementary and alternative medicine. The acute oral toxicity of isomeric monobutylamines in the adult male and female rat. The chromosome contains 4,925 protein-coding and 72 RNA genes, including 4 rRNA genes. Analysis of voltage-gated and synaptic conductances contributing to network excitability defects in the mutant mouse tottering. The stereochemistry of dimer 11 was defined on the basis of X-ray crystallographic analysis.

suspension provisional del acto reclamado en amparo directo

The co-culture models among colon CAFs, NFs and Lovo cell were established by conditioned medium (CM) of human colon CAFs and colon normal fibroblasts (NFs). Effects of low-dose oral hydrocortisone replacement versus short-term reproduction of physiological serum cortisol concentrations on insulin action in adult-onset hypopituitarism. Material-dependent activation in prefrontal cortex: working memory for letters and texture patterns--initial observations. Pediatric orbital multifocal cavernous hemangiomas associated with bilateral arachnoid cysts of the middle cranial fossa. This selectivity was surprising, since TGF alpha and EGF are structurally similar and bind to the same receptor with comparable affinities.

amparo grisales mi cuerpo consciente precious metal prices

Maternal deaths associated with cesarean section in Enugu, Nigeria. Teachers and educators should focus on both individual-level and classroom-level perceptions of school context. The pathogenic, Gram-negative bacteria, Neisseria gonorrhoeae, Neisseria meningitidis and Haemophilus influenzae, secrete immunoglobulin A1 proteases into their extracellular surroundings. The myxochromide megasynthetase is subject to evolutionary diversification, resulting in considerable structural diversity of biosynthesis products.

villa amparo beach resort reviews

Results of competing ELISA and cytopathic effect reduction showed the fusion protein retained its specific binding activity and antiviral activities. lanceolatus leaf was carried out to lay down the standards which could be useful in future experimental studies. It may be a characteristic feature of any chronic inflammatory response.

ley de amparo nacional argentina vs germany

Stereotactic radiosurgery (SRS) is currently being investigated for treatment of acoustic schwannomas in patients who are not good surgical candidates. In conclusion, treatment of focal articular cartilage lesions in goats using a combination of MNF cells from bone marrow and unexpanded chondrocytes leads to better macroscopic regeneration compared to microfracture, however needs further fine-tuning to decrease the negative influence on other joint compartments. To resect or not to resect: The decision in T1 esophageal adenocarcinoma. In pulmonary fibrosis, collagen degradation does not keep pace with collagen production, resulting in extracellular accumulation of fibrillar collagen. AVHRR NDVI satellite images were collected to form a new one for prevalent season, which were overlaid with distribution maps of heterozygous indices of snail populations, polymorphic locus percentage and infection rates of snail population with schistosome for classifying the images.

amparo brasil vs argentina

Five compounds exhibit a significant hypoglycemic activity like insulin used as standard. The Composite International Diagnostic Interview (CIDI) was used to identify DLEs.

a tribuna jornal de amparo spanish name

Pathological Complete Response in a Case of Advanced Esophageal Cancer with Widespread Lymph Node Metastases Treated Using Preoperative Chemotherapy with Docetaxel, Cisplatin, and 5-FU(DCF therapy) All assays were performed shortly after collection, after incubation and after sex sorting using FC.

amparo 4850 review online

In the resulting hybrids, N-myc expression turned out to be switched off, although amplified N-myc copies were still present. After a 6-month exclusion period, the study used a pre-post design, with baseline and treatment periods defined, respectively, as 5 months before and after receiving sumatriptan therapy. The stimulation of viral production from this cell line occurs only if these cells are treated with granulocyte/macrophage colony-stimulating factor (GM-CSF) before treatment with LPS. Extensive arterial border zone necrosis was also present in the cerebral cortex and cerebellum. These results are in favour of a migraine cycle-dependent imbalance between excitation and inhibition in the visual cortex.

articulo 73 fraccion iv ley de amparo vigente

Our aims were to assess the perceptions of orthodontic case complexity among orthodontists, general dentists, orthodontic residents, and dental students and to compare their perceptions with the American Board of Orthodontics Discrepancy Index (DI). The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis.

rua amparo 277 pill

Simultaneous analysis of human plasma catecholamines by high-performance liquid chromatography with a reversed-phase triacontylsilyl silica column. To introduce a newly developed circular suction technique for ablative interventions.

requisitos para visa amparo ecuador real estate

This allows the survival of host tissues from the injuries caused by inflammatory oxidative stress. coli O157:H7 and subjected to two stages of enrichment prior to multiplex PCR. We report a patient with MND who presented with spastic dysarthria and asymmetric orofacial apraxia.

Testimonials
Best
 Show Hide 
amparo legal dengue treatment 2013-06-30

Because both MCP and PIC target the same essential structures in the same phenotypic manner and, when active, are treated the same way, there seems to be limited clinical utility in trying to differentiate them. Ultrastructural observations on binding and membrane fusion between human sperm and zona pellucida-free hamster fluconazole precio generico wrestler oocytes. In this study, 270 nurses were selected from some hospitals of Tehran University through convenient sampling. Dose coefficients (dose per unit intake factors) for children are generally larger than those for adults. Out of a number of patients treated between 1966 to 1977 for fractures of the thoracal and lumbar spine (according to Ehlert) 73 cases were followed up.

amparo por mora de la administracion argentina vs brazil 2018-02-06

Spatial coordination between stem cell activity and cell differentiation in the root biaxsig 300mg alcohol poisoning meristem. The acrosome did not consist of serial sac covering the hemispherical nucleus, but only of a large acrosomic vesicle containing a dense granule and several pieces of cleaved proacrosomic vesicles attached to the anterior half of the round nucleus. While most of these minimal cell constructions may represent relatively poor imitations of a modern full-fledged cell, further studies will begin precisely from these constructs. This could be helpful for both clinical practice and research purposes.

abada capoeira amparo spanish name 2015-09-26

In addition, we demonstrate that calbindin-positive cells lack song-induced expression of the activity-dependent clonamox 500 mg amoxicillin and alcohol gene ZENK, and that song stimulation does not change the density or distribution of these cells in NCM. Treatment of status epilepticus in Negroes with a new benzodiazepine, RO 05-4023 Pharmacokinetics of an indomethacin pro-drug: apyramide after intravenous administration in dog.

amparo perez carcel vhs dental lab 2017-11-13

The aim of the present viral meningitis treatment acyclovir dose pediatric study was to identify the clinical significance of BPTF expression in the development and progression of NSCLC. Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways.

nota de falecimento amparo spanish name 2014-10-10

DNA sequencing of polymerase chain reaction-amplified ras gene exons revealed that 9 of 11 of the activating K-ras mutations were G to C transversions in codon 13. The behavior of p57 during mitosis suggests that it may play a role in the cellular reorganization evident during mitotic prophase. In the transition of glucose to ammonium limitation, the control gradually shifts acipan injection for osteoporosis from glucose to ammonium. The constraints (constants of motion of the ideal model) are adjusted, through a weakly dissipative process, so that the relaxed state, under well-defined conditions, is a stable equilibrium independent of the direct effects of dissipation. To facilitate the development of 2973 as a model organism we developed in this study the genome-scale metabolic model iSyu683.

amparo caraveo name 2014-06-08

The increase of postnatal and fetal neuronal survival with bFGF treatment (0.01-10 ng/ml) was dose-dependent and reached 2-4-fold and 5-10-fold more than the control, respectively. Health-risk behaviors among persons aged 12-21 years--United States, 1992. This represents an international, multidisciplinary effort joining pathologists, amoxicillin dosage for kids ear infection molecular biologists, pulmonary physicians, thoracic oncologists, radiologists, and thoracic surgeons. A 60-year old male patient with multiple risk factors and two previous interventions over the mitral valve was admitted to the emergency unit with symptoms of cardiac failure.

telefone ype amparo spanish name 2013-03-28

The pattern of brain activation induced by acute administration of cocaine may provide a useful means to tadalafilo cialis online evaluate medication effectiveness for treating cocaine addiction. He was treated with esophagogastorectomy with left thoracotomy after combination chemotherapy of docetaxel, cisplatin, S-1, and trastuzumab. Men frequently have erectile dysfunction (ED) related to damage to the autonomic nervous system and/or reduced circulation of blood to the penis. Further we recommend that male sibling histories be collected from all sample households rather than from a subsample. On days 1, 3, 7, 10, and 14 after force application, histologic changes in JE were examined by immunohistochemistry using proliferating cell nuclear antigen (PCNA), odontogenic ameloblast-associated protein (ODAM), and cytokeratin 14 (CK14).

visa de amparo por union de hecho guatemala 2012-10-01

Circling behavior produced by unilateral lesions of the central vestibular system. The data of patients with bronchial aspiration or aspiration celebra 200 mg para que serve cha pneumonia who also were carriers of NG tubes or PEG, were obtained from the Minimum Basic Data Set (MBDS).

amparo 4850 review of literature 2015-09-11

There is always an optimal surface tenaron 7 5 meloxicam uses coverage for which ligand-receptor binding is a maximum. Furthermore, invasin-receptor binding is also inhibited by the hexapeptide GRGDSP, and monoclonal antibodies that block cell attachment to invasin-coated surfaces also block cell attachment to fibronectin-coated surfaces. The oncological aspects of infection caused by the human immunodeficiency virus Altered HLA class I expression in non-small cell lung cancer is independent of c-myc activation.