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Dutasteride

Dutasteride is a synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver.

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Dutasteride is used alone or with another medication (tamsulosin [Flomax]) to treat benign prostatic hyperplasia (BPH; enlargement of the prostate gland). Dutasteride is used to treat symptoms of BPH and may reduce the chance of developing acute urinary retention (sudden inability to urinate). Dutasteride may also decrease the chance that prostate surgery will be needed. Dutasteride is in a class of medications called 5-alpha reductase inhibitors. It works by blocking the production of a natural substance that enlarges the prostate.

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Records of telephone consultations made by microbiology registrars (SpR) on the Laboratory Information Management System (LIMS) over a 6 month period were analysed with regard to who initiated contact and the type of advice provided. Four-drug combination chemotherapy for advanced cervical carcinoma. Patients were randomly assigned by a computer-generated randomization sequence to receive either three-incision open esophagectomy or minimally invasive esophagectomy. Ptosis of one or both eyelids is a problem which affects a small, but nonetheless significant, portion of the population.

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Advances in diagnosis and spatial analysis of cysticercosis and taeniasis. Although careful attention to technical detail is required, mean blood flow measurements in individual cerebral vessels is feasible using a cine phase-contrast MR pulse sequence. Progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress.

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A 70-year-old woman had primary thrombocythemia for three years. Two prospective studies conducted in a neonatal and paediatric intensive care unit demonstrated a significant association of coronavirus-positive nasopharyngal samples with respiratory illness in hospitalised preterm neonates. The methodological approach described here provides a simple yet elegant way of identification of staphylococci. It remains unclear why only the proband among the pedigree had skin malignancies, however, the skin carcinogenesis might have been related to occupational radiation exposure. Oral ondansetron (GR 38032F) for the control of CMF-induced emesis in the outpatient.

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We reviewed medical records and obtained clinical data during the acute illness and follow-up data on neurologic sequelae. Here, we characterized a rice (Oryza sativa L.) male sterile mutant. To identify predictors of chronic pulmonary vein (PV) reconnection (CPVR) after successful circumferential PV isolation (CPVI) for atrial fibrillation (AF). Concern has been raised that medications that block serotonin reuptake may affect bone metabolism, resulting in bone loss. Evidence of low prevalence of mycobacterial lymphadenitis in wild boars (Sus scrofa) in Poland.

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The purpose of this study was to examine the reading comprehension processes of deaf children during the reading of narrative text by exploring the predictions they made when the material confirmed and did not confirm their expectations. A 47-year-old man was admitted to our hospital with complaints of cough and shortness of breath. However, there are only few instances that have reached the approval for clinical use. It further allows (i) a straightforward implementation of the dissociation characteristics, as evaluated from titration experiments, of the ionogenic charged groups distributed throughout the bacterial cell wall and/or the surrounding exopolymer layer and (ii) the inclusion of possible specific interactions between the charged groups and ions from the background electrolyte other than charge-determining ions.

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A flow analysis of subviral and viral particles in infected cells. Foxn4, a member of the forkhead box/winged-helix transcription factor superfamily, is expressed in mitotic progenitors and/or postmitotic precursors in both neural (e.g., retina and spinal cord) and non-neural tissues (e.g., atrioventricular canal and proximal airway). Seven patients underwent successful transplantation after a mean duration of 55 days of support (mean pump index was 3.1 L.min-1.m-2 during support). A computerized tomography scan showed an infarction in the right frontal lobe, and cerebral angiography revealed a false lumen and intimal flap at the A1 segment of the ACA. 23 (11 F, 12 M) healthy controls, 23 (8 F, 15 M) patients with acute viral hepatitis B (AVHB) and 25 (9 F, 16 M) patients with chronic viral hepatitis B (CVHB) were studied.

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The major technique of interventional angiology of the arteries of the thigh is percutaneous balloon dilatation (angioplasty). Expression and self-assembly of norwalk virus capsid protein from venezuelan equine encephalitis virus replicons. Diabetic Charcot joint mimicking acute osteomyelitis in radiography and three-phase radionuclide bone imaging study. Efficient working positions of seamstresses operating automatic sewing machines Measuring local tissue temperature is critical in establishing a rational approach for hyperthermia treatment of tumors.

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Surface MRA clearly demonstrated nidus adjacent to eloquent area and three-dimensional figures of feeding arteries and draining veins. Application of gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry to the analysis of chemical warfare samples, found to contain residues of the nerve agent sarin, sulphur mustard and their degradation products. Cholera toxin (CT), which is known to activate the endogenous level of cyclic adenosine monophosphate (cAMP) also inhibited TNF-alpha-induced LAK cell chemokinesis. Our study increases the range of clinical presentations associated with mutations in POLG gene, underlining some peculiar clinical features, such as PEO associated with corneal edema, and epilepsy, severe neuropathy with achalasia.

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positive atrophic gastritis is associated with differential mRNA expression of EGF receptor ligands. Should furosemide be avoided in acute right ventricular myocardial infarction?

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Most interestingly, in diapause-destined larvae, lower hemolymph titers of PTTH and reduced PTTH gene expression were observed for 4 and 2 days, respectively, prior to pupation. Substantial breast cancer risk reduction and potential survival benefit after bilateral mastectomy when compared with surveillance in healthy BRCA1 and BRCA2 mutation carriers: a prospective analysis.

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When the HeLa cell extract was supplemented with a combination of eIF2, eIF2B, and p97, the capacity to synthesize a protein from an uncapped mRNA became comparable to that from the capped counterpart stimulated with a combination of eIF2, eIF2B, and eIF4E. In cardiac-gated SPECT imaging, diagnosis relies on evaluation of the myocardial motion as well as perfusion. The present study was conducted to compare the bioavailability of two candesartan cilexetil 16 mg tablet formulations (test and reference formulations).

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Medical therapy for advanced stages of this condition has offered a minimal benefit and surgical treatment through transplantation is limited by the donor organ shortage. We observed an indirect increase in the expression of miR-138 after the transfection with hTERT short hairpin RNA (shRNA) plasmid in human malignant neuroblastoma SK-N-DZ and SK-N-BE2 cell lines. Failure to modulate autonomic reflex discharge by hippocampal stimulation in rabbits. With regard to biochemical parameters, serum alanine aminotransferase and cholesterol levels were correlated with 5-fluorouracil clearance. Oxygen and extracellular fluid restriction in cultured heart cells: electron microscopy studies.

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We have compared the tumorigenicity of the hybrids with the molecular mapping of chromosome 11 retained regions. The KSHV latency-associated nuclear antigen: a multifunctional protein. N-acetylserotonin and melatonin released into the medium was extracted and then quantified by radioimmunoassay. Psoriasis patients show elevated CECs and MPs, as a sign of endothelial dysfunction, which correlates with inflammatory markers as well as subclinical atherosclerosis and some capillaroscopy findings. The p5 transcript encodes the larger Rep proteins, Rep78 and Rep68, while the p19 transcript encodes the smaller proteins, Rep52 and Rep40.

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